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Initial Diagnostic Workup of Acute Leukemia


An interdisciplinary expert panel of hematologists and hematopathologists to systematically review published evidence to answer six questions for the initial diagnosis of acute leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), mixed-phenotype acute leukemia (MPAL), and acute leukemias of ambiguous lineage:

  1. What clinical and laboratory information should be available?
  2. What samples and specimen types should be evaluated?
  3. What tests are required for all patients during the initial evaluation?
  4. What tests are required for only a subset of patients?
  5. Where should laboratory testing be performed?
  6. How should the results be reported?

The College of American Pathologists' (CAP) Pathology and Laboratory Quality Center and the American Society of Hematology (ASH) collaborated to develop the clinical practice evidence-based guideline, "Initial Diagnostic Workup of Acute Leukemia: Guideline from the CAP and ASH," is available in the Archives of Pathology & Laboratory Medicine.

Guideline information

  • Guideline status: Active
  • Published online ahead of print: February 22, 2017
  • Originally published: October 2017

Guideline Tools and Resources

Download the following tools and resources to help implement the guideline:

Clinical teams should adopt the new guideline to improve diagnosis, treatment, and outcomes for acute leukemia patients.

External Endorsement

This guideline was endorsed by the American Society of Clinical Oncology on December 3, 2018.

Additional Resources for the Clinician Developed by ASH

Patient and Caregiver Resources

The CAP, ASH, and the Leukemia & Lymphoma Society created tools and resources to support patients with acute leukemia during their diagnosis and treatment. Download the following to learn more:

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